Presence of anti-RBC antibodies correlates with parasitaemia and once-infected RBCs but not the extent of post-malaria haemolysis

J Travel Med. 2024 Dec 10;31(8):taae045. doi: 10.1093/jtm/taae045.

Abstract

In a cohort of patients treated with oral artemisinin combination therapy for uncomplicated malaria, the presence of anti-red blood cell (RBC) auto-antibodies does not correlate with the extent of post-treatment haemolysis. Patients with positive antibody screening test on d14 had higher initial parasitaemia and a higher number of once-infected RBCs throughout follow-up.

MeSH terms

  • Adult
  • Antimalarials* / administration & dosage
  • Antimalarials* / therapeutic use
  • Artemisinins / administration & dosage
  • Artemisinins / therapeutic use
  • Autoantibodies / blood
  • Erythrocytes* / immunology
  • Erythrocytes* / parasitology
  • Female
  • Hemolysis*
  • Humans
  • Malaria / drug therapy
  • Malaria / immunology
  • Malaria, Falciparum / complications
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / immunology
  • Male
  • Middle Aged
  • Parasitemia* / drug therapy
  • Parasitemia* / immunology
  • Plasmodium falciparum / immunology

Substances

  • Antimalarials
  • Artemisinins
  • Autoantibodies