Novel Triazole-Containing "Dipeptides": Synthesis, Molecular Docking and Analgesic Activity Studies

Chembiochem. 2024 May 2;25(9):e202300837. doi: 10.1002/cbic.202300837. Epub 2024 Mar 27.

Abstract

Dipeptides of a new structure based on β-triazolalanines and (L)-α-amino acids were synthesized and optimal conditions were developed that ensure both chemical and optical purity of the final products. Molecular docking was carried out and possible intermolecular interactions of dipeptides with potential targets were established. Based on these studies, the analgesic property of chosen dipeptides was studied and it was found that some compounds possess revealed antinociceptive activity in the tail-flick test.

Keywords: analgesic activity; antinociceptive activity; molecular docking; α7-nAChRs; β-triazole dipeptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics* / chemical synthesis
  • Analgesics* / chemistry
  • Analgesics* / pharmacology
  • Animals
  • Dipeptides* / chemical synthesis
  • Dipeptides* / chemistry
  • Dipeptides* / pharmacology
  • Male
  • Mice
  • Molecular Docking Simulation*
  • Triazoles* / chemical synthesis
  • Triazoles* / chemistry
  • Triazoles* / pharmacology

Substances

  • Analgesics
  • Triazoles
  • Dipeptides