When a travel bug gets you down: severe, hypotensive African tick bite fever and response to therapy

Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662991.

Abstract

African tick bite fever, resulting from Rickettsia africae inoculation, is endemic in sub-Saharan Africa. We present a United States traveler with African tick bite fever 5 days after she returned from a mission trip to Zimbabwe. The patient exhibited symptomatic hypotension in addition to more typical findings, including fever, fatigue, and a necrotic eschar. The diagnosis was supported by histopathological findings and the patient's symptoms rapidly resolved with oral doxycycline therapy. We believe this case represents the first African tick bite fever diagnosis associated with symptomatic hypotension. This case additionally serves as a reminder of the importance of evaluating patient travel history.

MeSH terms

  • Doxycycline / therapeutic use
  • Female
  • Humans
  • Hypotension* / complications
  • Rickettsia Infections* / diagnosis
  • Rickettsia Infections* / drug therapy
  • Rickettsia Infections* / epidemiology
  • Spotted Fever Group Rickettsiosis* / complications
  • Tick-Borne Diseases* / diagnosis
  • Tick-Borne Diseases* / epidemiology
  • Tick-Borne Diseases* / microbiology
  • Travel

Substances

  • Doxycycline