A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process

Saade Abdalkareem Jasim; Sulieman Ibraheem Shelash Al-Hawary; Ahmed Hjazi; Irfan Ahmad; Irwanjot Kaur; Wesam R Kadhum; Adnan Taan Alkhafaji; Pallavi Ghildiyal; Mohammed Abed Jawad; Salim B Alsaadi

doi:10.1016/j.prp.2024.155229

A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process

Pathol Res Pract. 2024 Apr:256:155229. doi: 10.1016/j.prp.2024.155229. Epub 2024 Feb 27.

Affiliations

¹ Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq.
² Department of Business Administration, Business School, Al al-Bayt University, P.O.BOX 130040, Mafraq 25113, Jordan. Electronic address: dr_sliman73@aabu.edu.jo.
³ Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
⁴ Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia. Electronic address: irfan.ahmadd.1984@gmail.com.
⁵ Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka 560069, India; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan 303012, India.
⁶ Department of Pharmacy, Kut University College, Kut, Wasit 52001, Iraq; Advanced research center, Kut University College, Kut, Wasit 52001, Iraq.
⁷ Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq.
⁸ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
⁹ Department of Pharmaceutics, Al-Nisour University College, Baghdad, Iraq.
¹⁰ Department of Pharmaceutics, Al-Hadi University College, Baghdad 10011, Iraq.

PMID: 38484655
DOI: 10.1016/j.prp.2024.155229

Abstract

It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we briefly overview its biological action and related cancer-related pathways. Next, we mainly address the impact of CRNDE on the epithelial-mesenchymal transition (EMT). The epithelial-mesenchymal transition, or EMT, is an essential biological mechanism involved in the spread of cancer.

Keywords: CRNDE; Cancer progression; Epithelial-mesenchymal transition; Long noncoding RNA.

Publication types

Review

MeSH terms

Epithelial-Mesenchymal Transition / genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplastic Processes
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding
CRNDE RNA, human