Active roles of lytic polysaccharide monooxygenases in human pathogenicity

Abstract

Lytic polysaccharide monooxygenases (LPMOs) are redox enzymes widely studied for their involvement in microbial and fungal biomass degradation. The catalytic versatility of these enzymes is demonstrated by the recent discovery of LPMOs in arthropods, viruses, insects and ferns, where they fulfill diverse functions beyond biomass conversion. This mini-review puts a spotlight on a recently recognized aspect of LPMOs: their role in infectious processes in human pathogens. It discusses the occurrence and potential biological mechanisms of LPMOs associated with human pathogens and provides an outlook on future avenues in this emerging and exciting research field.

Keywords: Cryptococcus neoformans; Human pathogens; Lytic polysaccharide monooxygenase; Oxidoreductase; Pseudomonas aeruginosa; Vibrio cholerae.