NLRP3 inflammasome in sepsis: don't overlook the small steps-they can make a big difference!

Felicie Belicard; Karin Tarte; Jean-Marc Tadié

doi:10.1093/jleuko/qiae056

NLRP3 inflammasome in sepsis: don't overlook the small steps-they can make a big difference!

J Leukoc Biol. 2024 May 29;115(6):999-1001. doi: 10.1093/jleuko/qiae056.

Authors

Felicie Belicard^{1

2}, Karin Tarte^{1

2}, Jean-Marc Tadié^{1

2

3}

Affiliations

¹ Department of Infectious Diseases and Intensive Care Unit, CHU Rennes, 35000 Rennes, France.
² French Blood Establishment and SITI Laboratory, UMR U1236, INSERM, University of Rennes, University Hospital Center of Rennes, 35000 Rennes, France.
³ Inserm, Centre d'investigation clinique de Rennes (CIC1414), CHU Rennes, 35000 Rennes, France.

PMID: 38498595
DOI: 10.1093/jleuko/qiae056

Abstract

"In sepsis, persistent activation of NLRP3 is associated with expansion of both monocytic and granulocytic MDSCs, along with high plasma concentration of IL-10."

Keywords: NLRP3 inflammasome; immunosuppression; sepsis.

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Publication types

Editorial
Comment

MeSH terms

Animals
Humans
Inflammasomes* / metabolism
Interleukin-10 / metabolism
Myeloid-Derived Suppressor Cells / immunology
Myeloid-Derived Suppressor Cells / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
Sepsis* / immunology
Sepsis* / metabolism

Substances

NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes
Interleukin-10