Habituation disorders in auditory middle latency response of persistent postural-perceptual dizziness patients

Toshihisa Murofushi; Fumiyuki Goto; Munetaka Ushio

doi:10.3389/fneur.2024.1366420

Habituation disorders in auditory middle latency response of persistent postural-perceptual dizziness patients

Front Neurol. 2024 Mar 6:15:1366420. doi: 10.3389/fneur.2024.1366420. eCollection 2024.

Authors

Toshihisa Murofushi¹, Fumiyuki Goto², Munetaka Ushio³

Affiliations

¹ Department of Otolaryngology, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan.
² Department of Otolaryngology-Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
³ Department of Otolaryngology, Toho University Medical Center Sakura Hospital, Sakura, Japan.

Abstract

Objectives: To study habituation disorders in auditory middle latency response (AMLR) to repetitive stimuli of persistent postural-perceptual dizziness (PPPD) patients.

Subjects: Twenty-eight PPPD (10 men and 18 women, mean 59.5 years of age, 26-81 years of age) were enrolled. For comparison, data of 13 definite vestibular migraine (VM) patients (3 men, 10 women, mean age 45.5), 13 definite unilateral Meniere's disease (MD) patients (2 men, 11 women, mean age 50.6), and 8 healthy control (HC) subjects (2 men, 6 women, mean age 37.1) in the previous study were utilized.

Methods: The electrodes were placed on the vertex and the spinal process of the fifth cervical vertebra. Clicks (0.1 msec, 70 dB nHL) were binaurally presented and averaged (800 times). Averaged responses were divided into 4 sets (S1 to S4) according to the temporal order. As peaks, Na, and Pa were identified, and relative Na-Pa amplitudes in S2-S4 to S1 were analyzed.

Results: The mean relative amplitude of PPPD patients showed lack of habituation (potentiation) as shown in VM patients, although the extent of potentiation was weaker than VM. Comparison of relative S4 amplitudes showed significant differences among the 4 groups (p = 0.0013 one-way ANOVA), Multiple comparison revealed significant differences between PPPD and MD (p = 0.0337 Dunnet's test).

Conclusion: PPPD patients showed lack of habituation (potentiation) of Na-Pa amplitude in AMLR to repetitive stimuli. Lack of habituation (potentiation) might be associated with sensory processing disorders in PPPD.

Keywords: PPPD; habituation; potentiation; sensory gating; sensory processing disorder; vestibular migraine.

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by a Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (19K09856).