Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5

Chem Biodivers. 2024 Jun;21(6):e202400507. doi: 10.1002/cbdv.202400507. Epub 2024 Apr 12.

Abstract

Three new C10 and C12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.

Keywords: Aliphatic δ-lactone; Anti-inflammation; Aureobasidium sp.; Deep-sea; Fatty acid methyl ester; Fungus.

MeSH terms

  • Animals
  • Aureobasidium* / chemistry
  • Aureobasidium* / metabolism
  • Cell Line
  • Lactones
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Nitric Oxide* / antagonists & inhibitors
  • Nitric Oxide* / biosynthesis
  • Nitric Oxide* / metabolism

Substances

  • Lipopolysaccharides
  • Nitric Oxide
  • Lactones