The Emergence of Candida auris is Not Associated with Changes in Antifungal Prescription at Hospitals

Shuk-Ching Wong; Pui-Hing Chau; Hong Chen; Simon Yung-Chun So; Kelvin Hei-Yeung Chiu; Jonathan Hon-Kwan Chen; Xin Li; Celine Sze-Ling Chui; Kwok-Yung Yuen; Vincent Chi-Chung Cheng

doi:10.2147/IDR.S451742

The Emergence of Candida auris is Not Associated with Changes in Antifungal Prescription at Hospitals

Infect Drug Resist. 2024 Apr 11:17:1419-1429. doi: 10.2147/IDR.S451742. eCollection 2024.

Authors

Affiliations

¹ Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, People's Republic of China.
² School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
³ Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, People's Republic of China.
⁴ Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
⁵ School of Clinical Medicine, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
⁶ School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Abstract

Purpose: This study describes the emergence of Candida auris in Hong Kong, focusing on the incidence and trends of different Candida species over time. Additionally, the study analyzes the relationship between C. auris and antifungal prescription, as well as the impact of outbreaks caused by C. auris.

Patients and methods: Data were collected from 43 public hospitals across seven healthcare networks (A to G) in Hong Kong, including Candida species culture and antifungal prescription information. Among 150,267 patients with 206,405 hospitalization episodes, 371,653 specimens tested positive for Candida species. Trends in Candida species and antifungal prescription were analyzed before (period 1: 2015 1Q to 2019 1Q) and after (period 2: 2019 2Q to 2023 2Q) the emergence of C. auris in Hong Kong.

Results: Candida albicans was the most prevalent species, accounting for 57.1% (212,163/371,653) of isolations, followed by Candida glabrata (13.1%, 48,666), Candida tropicalis (9.2%, 34,261), and Candida parapsilosis (5.3%, 19,688). C. auris represented 2.0% of all Candida species isolations. Comparing period 2 to period 1, the trend of C. albicans remained stable, while C. glabrata, C. tropicalis, and C. parapsilosis demonstrated a slower increasing trend in period 2 than in period 1. Other species, including C. auris, exhibited a 1.1% faster increase in trend during period 2 compared to period 1. Network A, with the highest antifungal prescription, did not experience any outbreaks, while networks F and G had 40 hospital outbreaks due to C. auris in period 2. Throughout the study period, healthcare networks B to G had significantly lower antifungal prescription compared to network A, ranging from 54% to 78% less than that of network A.

Conclusion: There is no evidence showing correlation between the emergence of C. auris and antifungal prescription in Hong Kong. Proactive infection control measures should be implemented to prevent nosocomial transmission and outbreak of C. auris.

Keywords: antifungal prescription; epidemiology; infection control measure; outbreak.

Grants and funding

This study was partially supported by the Health and Medical Research Fund (HMRF), Commissioned Research on Control of Infectious Disease (Phase IV), CID-HKU1-16, Health Bureau, Hong Kong SAR Government.