Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers

Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00004.2024. Epub 2024 Apr 16.

Abstract

Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to organismal death. Examining the survival mechanisms influenced by metabolism and environment, this research has the potential to transform regenerative medicine, redefine legal death, and provide insights into life's physiological limits, paralleling inquiries in embryogenesis.

Keywords: organismal death; physiological limits; survival mechanisms; transformation; transitions.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Death*
  • Humans