Turn-on fluorescent aptasensing for the determination of serotonin via target-induced knot displacement at corona

M A Hagir Omer; Danyang Zhang; Wenshuai Zhou; Xiaolin Yang; Honglan Qi

doi:10.1039/d4cc00934g

Turn-on fluorescent aptasensing for the determination of serotonin via target-induced knot displacement at corona

Chem Commun (Camb). 2024 May 2;60(37):4926-4929. doi: 10.1039/d4cc00934g.

Authors

M A Hagir Omer¹, Danyang Zhang¹, Wenshuai Zhou¹, Xiaolin Yang¹, Honglan Qi¹

Affiliation

¹ Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China. xlyang@snnu.edu.cn.

PMID: 38629227
DOI: 10.1039/d4cc00934g

Abstract

A turn-on fluorescence aptasensing approach for the highly sensitive and selective determination of 5-HT was proposed via target-induced knot displacement. 5-HT can be determined in a range from 0.5 nM to 100 nM with a limit of detection as low as 0.1 nM and a low dissociation constant of 2.3 nM.

MeSH terms

Aptamers, Nucleotide* / chemistry
Biosensing Techniques* / methods
Fluorescence
Fluorescent Dyes* / chemistry
Humans
Limit of Detection
Serotonin* / analysis
Serotonin* / chemistry
Spectrometry, Fluorescence*

Substances

Aptamers, Nucleotide
Serotonin
Fluorescent Dyes