Photo- and Cu-Mediated 11C Cyanation of (Hetero)Aryl Thianthrenium Salts

Org Lett. 2024 Apr 26;26(16):3419-3423. doi: 10.1021/acs.orglett.4c00929. Epub 2024 Apr 17.

Abstract

We present a photo- and Cu-mediated 11C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.