Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner

Blood. 2024 Jun 20;143(25):2666-2670. doi: 10.1182/blood.2024024620.

Abstract

Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bone and Bones / metabolism
  • Collagen / metabolism
  • Extracellular Matrix Proteins
  • Female
  • Gene Deletion
  • Male
  • Megakaryocytes* / cytology
  • Megakaryocytes* / metabolism
  • Mice
  • Mice, Knockout*
  • Protein-Lysine 6-Oxidase* / genetics
  • Protein-Lysine 6-Oxidase* / metabolism
  • Sex Characteristics
  • Sex Factors

Substances

  • Protein-Lysine 6-Oxidase
  • Lox protein, mouse
  • Collagen
  • Extracellular Matrix Proteins