Lymphoid tissue on the mind

Trends Immunol. 2024 May;45(5):325-326. doi: 10.1016/j.it.2024.04.002. Epub 2024 Apr 17.

Abstract

To surveil an organ for pathogens, lymphoid structures need to sample antigens locally. The full set of lymphoid structures involved in surveilling for brain-tropic pathogens has not been defined. Through comprehensive imaging of the mouse meninges, a new study by Fitzpatrick et al. describes dural-associated lymphoid tissue (DALT) and its contribution to humoral responses following intranasal viral infection.

MeSH terms

  • Animals
  • Brain / immunology
  • Brain / physiology
  • Brain / virology
  • Humans
  • Immunity, Humoral
  • Lymphoid Tissue* / immunology
  • Lymphoid Tissue* / virology
  • Meninges / immunology
  • Mice