Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension

Circulation. 2024 Apr 23;149(17):1372-1374. doi: 10.1161/CIRCULATIONAHA.124.068738. Epub 2024 Apr 22.
No abstract available

Keywords: Editorials; adenosine; energy metabolism; hypertension, pulmonary; malate dehydrogenase (decarboxylating).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Editorial
  • Comment

MeSH terms

  • Adenosine* / metabolism
  • Animals
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Energy Metabolism* / drug effects
  • Humans
  • Hypertension, Pulmonary* / drug therapy
  • Hypertension, Pulmonary* / metabolism
  • Malate Dehydrogenase* / antagonists & inhibitors
  • Malate Dehydrogenase* / metabolism
  • Signal Transduction* / drug effects

Substances

  • Adenosine
  • Malate Dehydrogenase