Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases

Binhui Zhou; Mengjie Zhang; Haoyuan Ma; Ying Wang; Juanjuan Qiu; Yang Liu; Liaoxun Lu; Tianhan Li; Lichen Zhang; Rong Huang; Yanrong Gu; Eryan Kong; Yinming Liang

doi:10.1038/s41423-024-01166-6

Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases

Cell Mol Immunol. 2024 Jul;21(7):787-789. doi: 10.1038/s41423-024-01166-6. Epub 2024 May 8.

Authors

Binhui Zhou^#^{1

2

3}, Mengjie Zhang^#⁴, Haoyuan Ma^#⁴, Ying Wang^#^{5

6}, Juanjuan Qiu⁴, Yang Liu⁴, Liaoxun Lu⁴, Tianhan Li⁷, Lichen Zhang⁴, Rong Huang⁴, Yanrong Gu⁴, Eryan Kong^{8

9}, Yinming Liang^{10

11

12}

Affiliations

¹ Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China. zhoubinhui@gris.org.cn.
² Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, 453003, China. zhoubinhui@gris.org.cn.
³ Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, China. zhoubinhui@gris.org.cn.
⁴ Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, China.
⁵ Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China.
⁶ Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, 453003, China.
⁷ Basic Medical College, Xinxiang Medical University, Xinxiang, 453003, China.
⁸ Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China. eykong2012@163.com.
⁹ Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, 453003, China. eykong2012@163.com.
¹⁰ Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, 453003, China. yinming.liang@gris.org.cn.
¹¹ Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, China. yinming.liang@gris.org.cn.
¹² Center of Disease Model and Immunology, Hunan Academy of Chinese Medicine, Changsha, China. yinming.liang@gris.org.cn.

^# Contributed equally.

PMID: 38720064
PMCID: PMC11214613 (available on 2025-07-01)
DOI: 10.1038/s41423-024-01166-6

No abstract available

Publication types

Letter

MeSH terms

Acyltransferases* / metabolism
Animals
Forkhead Transcription Factors* / metabolism
Humans
Lipoylation*
Mice
T-Lymphocytes, Regulatory* / immunology

Substances

Forkhead Transcription Factors
Acyltransferases
Foxp3 protein, mouse

Grants and funding

32000491/National Natural Science Foundation of China (National Science Foundation of China)