Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients

Shiwen Li; Yuyuan Lin; Dean Jones; Douglas I Walker; Aline Duarte Folle; Irish Del Rosario; Yu Yu; Keren Zhang; Adrienne M Keener; Jeff Bronstein; Beate Ritz; Kimberly C Paul

doi:10.1038/s41531-024-00711-4

Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients

NPJ Parkinsons Dis. 2024 May 10;10(1):100. doi: 10.1038/s41531-024-00711-4.

Authors

Shiwen Li¹, Yuyuan Lin¹, Dean Jones^{2

3}, Douglas I Walker⁴, Aline Duarte Folle¹, Irish Del Rosario¹, Yu Yu⁵, Keren Zhang¹, Adrienne M Keener⁶, Jeff Bronstein⁶, Beate Ritz^{1

6}, Kimberly C Paul⁷

Affiliations

¹ Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
² Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, USA.
³ Department of Biochemistry, Emory University School of Medicine, Atlanta, USA.
⁴ Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
⁵ Center for Health Policy Research, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
⁶ Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.
⁷ Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. kimberlp@ucla.edu.

Abstract

Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson's disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis. After adjusting for multiple testing, in positive (or negative) ion mode, 30 (25) metabolic features were associated with T2DM in both PD and non-PD participants, 162 (108) only in PD participants, and 32 (7) only in non-PD participants. Pathway enrichment analysis identified 17 enriched pathways associated with T2DM in both the PD and non-PD participants, 26 pathways only in PD participants, and 5 pathways only in non-PD participants. Several amino acid, nucleic acids, and fatty acid metabolisms were associated with T2DM only in the PD patient group suggesting a possible link between PD and T2DM.

Grants and funding

U01 AG060908/AG/NIA NIH HHS/United States