Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease

Qian Liu; Thames Pickett; Deborah Hodge; Carmen Rios; Michelle Arnold; Gang Dong; Sara E Hamilton; Barbara Rehermann

doi:10.1038/s41590-024-01842-9

Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease

Nat Immunol. 2024 Jun;25(6):947-950. doi: 10.1038/s41590-024-01842-9.

Authors

Qian Liu¹, Thames Pickett², Deborah Hodge³, Carmen Rios³, Michelle Arnold², Gang Dong³, Sara E Hamilton⁴, Barbara Rehermann⁵

Affiliations

¹ Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Rockville, MD, USA. liujoy@niaid.nih.gov.
² Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Rockville, MD, USA.
³ Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Rockville, MD, USA.
⁴ Department of Laboratory Medicine & Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
⁵ Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA. Rehermann@nih.gov.

Abstract

The National Institute of Allergy and Infectious Diseases (NIAID) hosted a two-day virtual workshop on leveraging microbial exposure to improve mouse models of human immune status and disease. The workshop’s objective was to evaluate the current state of knowledge in the field and to identify gaps, challenges and future directions.

MeSH terms

Animals
Disease Models, Animal*
Humans
Mice