Not too much, not too little-just the right amount: the story of YAP in the podocyte

Kidney Int. 2024 Jun;105(6):1157-1159. doi: 10.1016/j.kint.2024.02.016.

Abstract

Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms' tumor 1, and worsened podocyte injury in a mouse model of diabetic kidney injury. Yes-associated protein may therefore play a critical role in diabetic podocyte injury via regulation of Wilms' tumor 1 expression.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing* / genetics
  • Adaptor Proteins, Signal Transducing* / metabolism
  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Diabetic Nephropathies* / etiology
  • Diabetic Nephropathies* / metabolism
  • Diabetic Nephropathies* / pathology
  • Humans
  • Mice
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Podocytes* / metabolism
  • Podocytes* / pathology
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism
  • WT1 Proteins* / genetics
  • WT1 Proteins* / metabolism
  • YAP-Signaling Proteins* / metabolism

Substances

  • YAP-Signaling Proteins
  • Transcription Factors
  • Adaptor Proteins, Signal Transducing
  • WT1 Proteins
  • Yap1 protein, mouse
  • Phosphoproteins
  • YAP1 protein, human
  • Cell Cycle Proteins