Abstract
Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms' tumor 1, and worsened podocyte injury in a mouse model of diabetic kidney injury. Yes-associated protein may therefore play a critical role in diabetic podocyte injury via regulation of Wilms' tumor 1 expression.
Copyright © 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Adaptor Proteins, Signal Transducing* / genetics
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Adaptor Proteins, Signal Transducing* / metabolism
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Animals
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Diabetic Nephropathies* / etiology
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Diabetic Nephropathies* / metabolism
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Diabetic Nephropathies* / pathology
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Humans
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Mice
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Phosphoproteins / genetics
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Phosphoproteins / metabolism
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Podocytes* / metabolism
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Podocytes* / pathology
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Transcription Factors* / genetics
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Transcription Factors* / metabolism
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WT1 Proteins* / genetics
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WT1 Proteins* / metabolism
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YAP-Signaling Proteins* / metabolism
Substances
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YAP-Signaling Proteins
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Transcription Factors
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Adaptor Proteins, Signal Transducing
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WT1 Proteins
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Yap1 protein, mouse
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Phosphoproteins
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YAP1 protein, human
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Cell Cycle Proteins