Recent Advances in the Synthesis of Rosettacin

Xiao Tang; Yukang Jiang; Liangliang Song; Erik V Van der Eycken

doi:10.3390/molecules29102176

Recent Advances in the Synthesis of Rosettacin

Molecules. 2024 May 7;29(10):2176. doi: 10.3390/molecules29102176.

Authors

Xiao Tang¹, Yukang Jiang¹, Liangliang Song², Erik V Van der Eycken^{3

4}

Affiliations

¹ College of Science, Nanjing Forestry University, Nanjing 210037, China.
² Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
³ Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium.
⁴ Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia.

Abstract

Camptothecin and its analogues show important antitumor activity and have been used in clinical studies. However, hydrolysis of lactone in the E ring seriously attenuates the antitumor activity. To change this situation, aromathecin alkaloids are investigated in order to replace camptothecins. Potential antitumor activity has obtained more and more attention from organic and pharmaceutical chemists. As a member of the aromathecin alkaloids, rosettacin has been synthesized via different methods. This review summarizes recent advances in the synthesis of rosettacin.

Keywords: antitumor; aromathecin; camptothecin; heterocycle; rosettacin.

Publication types

Review

Grants and funding

This work was supported by the Natural Science Foundation of Jiangsu Province (BK20220409) (recipient: L.S., supervision and writing) and the Natural Science Research of Jiangsu Higher Education Institutions of China (22KJB150008) (recipient: L.S., supervision and writing). We acknowledge the Fund for Scientific Research-Flanders (Belgium) (FWO) for its financial support (1002720H and 1001920H) (recipient: E.V.V.d.E., supervision and writing) and the research council of KU Leuven (recipient: E.V.V.d.E., supervision and writing). This paper was prepared with the support of the “RUDN University Strategic Academic Leadership Program” (recipient: E.V.V.d.E., supervision and writing).