Plant-Derived Peptides: (Neglected) Natural Products for Drug Discovery

Planta Med. 2024 Jun;90(7-08):627-630. doi: 10.1055/a-2219-9724. Epub 2024 Jun 6.

Abstract

Peptides have emerged as key regulators in various physiological processes, including growth, development, stress, and defense responses within plants as well as ecological interactions of plants with microbes and animals. Understanding and harnessing plant peptides can lead to the development of innovative strategies for crop improvement, increasing agricultural productivity, and enhancing resilience to environmental challenges such as drought, pests, and diseases. Moreover, some plant peptides have shown promise in human health applications, with potential therapeutic benefits as ingredients in herbal medicines as well as novel drug leads. The exploration of plant peptides is essential for unraveling the mysteries of plant biology and advancing peptide drug discovery. This short personal commentary provides a very brief overview about the field of plant-derived peptides and a personal word of motivation to increase the number of scientists in pharmacognosy working with these fascinating biomolecules.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products* / chemistry
  • Biological Products* / pharmacology
  • Drug Discovery*
  • Humans
  • Peptides* / chemistry
  • Peptides* / pharmacology
  • Plant Proteins / chemistry
  • Plants / chemistry

Substances

  • Biological Products
  • Peptides
  • Plant Proteins