Abstract
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes.
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MeSH terms
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Animals
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Claudins* / genetics
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Claudins* / immunology
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Claudins* / metabolism
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Humans
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Immunological Synapses / immunology
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Immunological Synapses / metabolism
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Lung Neoplasms / immunology
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Lymphocyte Activation / immunology
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Neoplasms / immunology
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Pancreatic Neoplasms / immunology
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Claudins
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CLDN18 protein, human