Innate-like T cells in liver disease

Albert Ying-Po Yang; Kilian Wistuba-Hamprecht; Tim F Greten; Benjamin Ruf

doi:10.1016/j.it.2024.05.008

Innate-like T cells in liver disease

Trends Immunol. 2024 Jul;45(7):535-548. doi: 10.1016/j.it.2024.05.008. Epub 2024 Jun 14.

Authors

Albert Ying-Po Yang¹, Kilian Wistuba-Hamprecht², Tim F Greten³, Benjamin Ruf⁴

Affiliations

¹ Department of Internal Medicine I, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany; M3 Research Center for Malignome, Metabolome, and Microbiome, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
² Department of Internal Medicine I, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany; M3 Research Center for Malignome, Metabolome, and Microbiome, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) - Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany.
³ Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Center for Cancer Research (CCR) Liver Cancer Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁴ Department of Internal Medicine I, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany; M3 Research Center for Malignome, Metabolome, and Microbiome, Faculty of Medicine, University of Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) - Image-Guided and Functionally Instructed Tumor Therapies, University of Tübingen, Tübingen, Germany. Electronic address: benjamin.ruf@med.uni-tuebingen.de.

PMID: 38879436
DOI: 10.1016/j.it.2024.05.008

Abstract

Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis. This review explores the involvement of different ILTC subsets in liver diseases. We explore the mechanisms underlying the pro- and anti-inflammatory effector functions of ILTCs in a context-dependent manner. We highlight latest findings regarding the dynamic interplay between ILTC functional subsets and other immune and parenchymal cells which may inform candidate immunomodulatory strategies to achieve improved clinical outcomes in liver diseases. We present new insights into how distinct gene expression programs in hepatic ILTCs are induced, maintained, and reprogrammed in a context- and disease stage-dependent manner.

Keywords: ILTCs; MAIT; NKT; liver diseases; γδ T cells.

Publication types

Review

MeSH terms

Animals
Humans
Immunity, Innate*
Liver / immunology
Liver Diseases* / immunology
Mucosal-Associated Invariant T Cells / immunology
Natural Killer T-Cells / immunology
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism