A case of renal sarcoidosis complicated by parotid gland and uterine lesions

BMC Nephrol. 2024 Jun 18;25(1):198. doi: 10.1186/s12882-024-03635-6.

Abstract

Background: Sarcoidosis is a systemic disease that can affect multiple organs. While pulmonary sarcoidosis is most commonly observed, renal sarcoidosis occurs less frequently. We herein report a case of sarcoidosis with an exceptionally rare distribution including renal lesions.

Case presentation: A 51-year-old Japanese female was referred because of bilateral parotid swelling and renal dysfunction. Computed tomography scan showed the swelling of bilateral kidneys, parotid glands, and uterus. Ga scintigraphy also showed remarkable accumulation in these organs. Renal biopsy and cytological evaluations of parotid gland and uterus were performed and she was diagnosed as sarcoidosis of these organs. Treatment was initiated with prednisolone 40 mg/day and then renal dysfunction subsequently improved. In addition, the swelling of parotid glands and uterus improved and Ga accumulation in each organ had disappeared.

Conclusion: This is a first case of renal sarcoidosis complicated by parotid glands and uterus lesions. Pathological findings and the reactivity observed in Ga scintigraphy indicated the presence of lesions in these organs.

Keywords: Acute kidney injury; Parotid glands; Sarcoidosis; Uterus.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Kidney Diseases* / complications
  • Kidney Diseases* / diagnostic imaging
  • Kidney Diseases* / etiology
  • Kidney Diseases* / pathology
  • Middle Aged
  • Parotid Diseases / diagnostic imaging
  • Parotid Diseases / etiology
  • Parotid Diseases / pathology
  • Parotid Gland / diagnostic imaging
  • Parotid Gland / pathology
  • Prednisolone / therapeutic use
  • Radionuclide Imaging
  • Sarcoidosis* / complications
  • Sarcoidosis* / diagnostic imaging
  • Sarcoidosis* / drug therapy
  • Tomography, X-Ray Computed
  • Uterine Diseases / complications
  • Uterine Diseases / diagnostic imaging
  • Uterine Diseases / pathology

Substances

  • Prednisolone