Pharmacotherapy for older people with obesity

Eur J Intern Med. 2024 Dec:130:33-37. doi: 10.1016/j.ejim.2024.05.006. Epub 2024 Jun 18.

Abstract

Rates of obesity continue to rise, including in older adults. Use of medication for obesity in the elderly has been considered controversial, due to concerns around potential progression of age-related sarcopenia and a general lack of evidence for its use in this age group. Within this review, we describe the general considerations when prescribing obesity pharmacotherapy for older adults living with obesity. We evaluate in detail the anti-obesity medications currently licenced in Europe, with emphasis on the available efficacy, safety and cardiovascular outcome data gathered from study of older people. Finally, we discuss future directions and avenues of research.

Keywords: Elderly; Obesity; Older people; Pharmacotherapy; Sarcopenia.

Publication types

  • Review

MeSH terms

  • Aged
  • Anti-Obesity Agents* / adverse effects
  • Anti-Obesity Agents* / therapeutic use
  • Europe
  • Humans
  • Obesity* / drug therapy
  • Sarcopenia / drug therapy

Substances

  • Anti-Obesity Agents