Follicular lymphoma with blastic conversion: a report of two cases with confirmation by immunoperoxidase studies on bone marrow sections

Am J Clin Pathol. 1985 Jun;83(6):681-6. doi: 10.1093/ajcp/83.6.681.

Abstract

Two cases of low-grade follicular lymphoma are presented in which evolution to a blastic phase with marrow and peripheral blood involvement occurred. One case was a follicular and diffuse mixed-cell lymphoma, while the second was a follicular and diffuse small cleaved-cell lymphoma. In both cases, at two and three years after initial presentation, a clinical picture resembling acute leukemia developed, with immature blastic-appearing infiltrates in the bone marrow and circulating blastic cells. Immunoperoxidase studies on fresh frozen sections of bone marrow in both cases confirmed the B-cell nature of the infiltrates and excluded the clinical impression of acute non-lymphocytic leukemia. The differential diagnosis of hematolymphoid infiltrates in the bone marrow in patients with follicular lymphoma is discussed.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Monoclonal / immunology
  • Axilla
  • B-Lymphocytes / pathology
  • Biopsy
  • Bone Marrow / pathology*
  • Diagnosis, Differential
  • Frozen Sections
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques*
  • Lymph Nodes / pathology
  • Lymphoma / pathology
  • Lymphoma, Follicular / pathology*
  • Male
  • Middle Aged

Substances

  • Antibodies, Monoclonal