Objective: To investigate the effect of progression of disease within 24 months (POD24) on overall survival (OS) in patients with mantle cell lymphoma (MCL), and compare the clinical characteristics between POD24 and non-POD24 patients.
Methods: A retrospective analysis was performed on 50 MCL patients with treatment indications and regular treatment who were admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to August 2020. According to the occurrence of POD24, the patients were grouped for prognostic evaluation and clinical characteristics comparison.
Results: Univariate Cox regression analysis showed that POD24, PLT, albumin, MIPI score, ECOG PS score, LDH were the factors influencing OS in newly diagnosed MCL patients (all P < 0.05). The results of multivariate Cox regression analysis showed that POD24［HR=16.797(95%CI : 3.671-76.861),P < 0.001］, albumin<40 g/L［HR=3.238(95%CI :1.095-9.572),P =0.034］ and ECOG PS score≥2［HR=4.005(95%CI :1.033-15.521),P =0.045］ were independent risk factors influencing OS in MCL patients. The incidence of PLT<100×109/L (33.3% vs 5.9%, P =0.033) and ECOG PS score ≥2 (45.5% vs 5.9%, P =0.040) were significantly higher in POD24 patients than those in non-POD24 patients.
Conclusion: POD24 is an independent poor prognostic factor affecting the OS of MCL patients, and the patients with PLT<100×109/L and ECOG PS score≥2 at diagnosis have a higher probability of POD24.
题目: 24个月内疾病进展在套细胞淋巴瘤中的预后意义.
目的: 探讨24个月内疾病进展（POD24）对套细胞淋巴瘤（MCL）患者总生存的影响，比较POD24和非POD24患者的临床特征。.
方法: 回顾性分析2010年1月至2020年8月徐州医科大学附属医院收治的有治疗指征且经过正规治疗的MCL患者50例，根据POD24发生情况进行分组，进行预后评估及临床特征比较。.
结果: 单因素Cox回归分析结果显示，是否发生POD24、PLT、白蛋白、MIPI评分、ECOG PS评分、LDH均是影响初诊MCL患者OS的因素（P <0.05）。对单因素分析中有意义的指标进行多因素Cox回归分析，结果显示，发生POD24［HR=16.797(95%CI : 3.671-76.861),P =0.001］、白蛋白<40 g/L［HR=3.238(95%CI : 1.095-9.572), P =0.034］、ECOG PS≥2分［HR=4.005(95%CI :1.033-15.521), P =0.045］是影响MCL患者OS的独立危险因素。POD24患者较非POD24患者起病时PLT<100×109/L的发生率（33.3％ vs 5.9％,P ＝0.033）及ECOG PS≥2分的发生率（45.5％ vs 5.9％,P ＝0.040）明显增高。.
结论: POD24为影响MCL患者总生存的独立预后不良因素，起病时伴PLT<100×109/L、ECOG PS≥2分的患者发生POD24比例较高。.
Keywords: mantle cell lymphoma; progression of disease within 24 months; prognosis.