Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) in coronary artery disease and its correlation with inflammatory markers

Seyed Abdolhossein Tabatabaei; Reza Fadaei; Nariman Moradi; Vida Farrokhi; Akram Vatannejad; Reza Afrisham; Arash Falahat; Frood Malekshahi; Maryam Mirahmad; Ali Abbasi

doi:10.1007/s40200-024-01415-5

Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) in coronary artery disease and its correlation with inflammatory markers

J Diabetes Metab Disord. 2024 Apr 17;23(1):1233-1241. doi: 10.1007/s40200-024-01415-5. eCollection 2024 Jun.

Authors

Affiliations

¹ Department of Cardiology, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
² Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
³ Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
⁴ Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
⁶ Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 38932850
PMCID: PMC11196518 (available on 2025-04-17)
DOI: 10.1007/s40200-024-01415-5

Abstract

Introduction: Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) is an adipokine that is involved in regulation of glucose and lipid metabolism, inflammation, and insulin sensitivity. However, the exact role of CTRP6 in metabolic processes remains unclear due to conflicting findings. To address current gap, we aimed to investigate the serum levels of CTRP6 in patients with coronary artery disease (CAD) and its association with inflammatory cytokines.

Method: In this case-control study, the serum levels of CTRP6, interlukin-6 (IL-6), tumor necrosis factor- α (TNF-α), adiponectin, and fasting insulin were measured using enzyme-linked immunosorbent assay (ELISA) kits in a total of 176 participants, consisting of 88 CAD patients and 88 control subjects. Additionally, various anthropometric and biochemical measurements were measured and compared between cases and controls.

Results: The present study found that serum levels of CTRP6 were significantly higher in the CAD group (561.3 ± 15.14) compared to the control group (429.3 ± 12.85, p < 0.001). After adjusting for age, sex, and body mass index (BMI), CTRP6 levels were found to be positively associated with the risk of CAD (p < 0.001). Correlation analysis in CAD subjects revealed a positive correlation between CTRP6 levels and BMI, systolic blood pressure (SBP), malondialdehyde (MDA), TNF-α, and IL-6, as well as a negative correlation with creatinine and total anti-oxidant capacity.

Conclusion: The findings of this study provide novel evidence that elevated serum levels of CTRP6 are significantly associated with an increased risk of developing CAD. Moreover, our results indicate a correlation between CTRP6 and various risk factors for atherosclerosis.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-024-01415-5.

Keywords: CTRP6; Coronary artery disease; Inflammation; Insulin resistance; Lipid profile; Obesity.

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