Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma

Florian Chatelet; Alessandro Vinciguerra; Morgane Marc; Philippe Herman; Benjamin Verillaud

doi:10.1002/alr.23399

Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma

Int Forum Allergy Rhinol. 2024 Nov;14(11):1834-1837. doi: 10.1002/alr.23399. Epub 2024 Jun 27.

Authors

Florian Chatelet^{1

2}, Alessandro Vinciguerra¹, Morgane Marc^{1

2}, Philippe Herman^{1

2}, Benjamin Verillaud^{1

2}

Affiliations

¹ Otorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Paris, France.
² Faculté de Santé, UFR de Médecine, Université Paris Cité, Paris, France.

PMID: 38934682
DOI: 10.1002/alr.23399

Abstract

Intralesional cidofovir injections in combination with surgery is an effective treatment for recurrent multifocal sinonasal exophytic papilloma. No malignant transformation has been observed in our experience. Anosmia is a potential side effect that patients should be aware of.

Keywords: antiviral agents; cidofovir; exophytic papilloma; florid papillomatosis; human papillomavirus; nasal cavity papillomas; nasal tumor.

Publication types

Case Reports

MeSH terms

Antineoplastic Agents / administration & dosage
Antineoplastic Agents / therapeutic use
Cidofovir* / administration & dosage
Cidofovir* / therapeutic use
Cytosine* / administration & dosage
Cytosine* / analogs & derivatives
Cytosine* / therapeutic use
Female
Humans
Injections, Intralesional*
Male
Middle Aged
Organophosphonates* / administration & dosage
Organophosphonates* / therapeutic use
Papilloma* / drug therapy
Papilloma* / pathology
Paranasal Sinus Neoplasms / drug therapy
Paranasal Sinus Neoplasms / pathology
Treatment Outcome

Substances

Cidofovir
Cytosine
Organophosphonates
Antineoplastic Agents