Pan-RAF:MEK Molecular Glues Take Center Stage

Matthew J Hangauer; Jorge Silvio Gutkind; Fleur M Ferguson

doi:10.1158/2159-8290.CD-24-0539

Pan-RAF:MEK Molecular Glues Take Center Stage

Cancer Discov. 2024 Jul 1;14(7):1143-1144. doi: 10.1158/2159-8290.CD-24-0539.

Authors

Matthew J Hangauer^{1

2}, Jorge Silvio Gutkind^{3

2}, Fleur M Ferguson^{2

4

5}

Affiliations

¹ Department of Dermatology, University of California San Diego, La Jolla, California.
² UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.
³ Department of Pharmacology, University of California San Diego, La Jolla, California.
⁴ Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California.
⁵ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California.

PMID: 38946324
DOI: 10.1158/2159-8290.CD-24-0539

Abstract

In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).

MeSH terms

Animals
Humans
MAP Kinase Signaling System
Mice
Mitogen-Activated Protein Kinase Kinases / metabolism
Neoplasms / genetics
Neoplasms / metabolism
Protein Kinase Inhibitors* / pharmacology
Protein Kinase Inhibitors* / therapeutic use
raf Kinases / genetics
raf Kinases / metabolism

Substances

Protein Kinase Inhibitors
raf Kinases
Mitogen-Activated Protein Kinase Kinases