Cell-drug conjugates

Yanfang Wang; Jiaqi Shi; Minhang Xin; Anna R Kahkoska; Jinqiang Wang; Zhen Gu

doi:10.1038/s41551-024-01230-6

Cell-drug conjugates

Nat Biomed Eng. 2024 Nov;8(11):1347-1365. doi: 10.1038/s41551-024-01230-6. Epub 2024 Jul 1.

Authors

Yanfang Wang^{1

2}, Jiaqi Shi^{1

2}, Minhang Xin¹, Anna R Kahkoska³, Jinqiang Wang^{4

5

6

7}, Zhen Gu^{8

9

10

11

12

13}

Affiliations

¹ State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
² Jinhua Institute of Zhejiang University, Jinhua, China.
³ Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴ State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. jinqiang_wang@zju.edu.cn.
⁵ Jinhua Institute of Zhejiang University, Jinhua, China. jinqiang_wang@zju.edu.cn.
⁶ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. jinqiang_wang@zju.edu.cn.
⁷ Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. jinqiang_wang@zju.edu.cn.
⁸ State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn.
⁹ Jinhua Institute of Zhejiang University, Jinhua, China. guzhen@zju.edu.cn.
¹⁰ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn.
¹¹ Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn.
¹² Liangzhu Laboratory, Hangzhou, China. guzhen@zju.edu.cn.
¹³ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn.

PMID: 38951139
PMCID: PMC11646559 (available on 2025-05-01)
DOI: 10.1038/s41551-024-01230-6

Abstract

By combining living cells with therapeutics, cell-drug conjugates can potentiate the functions of both components, particularly for applications in drug delivery and therapy. The conjugates can be designed to persist in the bloodstream, undergo chemotaxis, evade surveillance by the immune system, proliferate, or maintain or transform their cellular phenotypes. In this Review, we discuss strategies for the design of cell-drug conjugates with specific functions, the techniques for their preparation, and their applications in the treatment of cancers, autoimmune diseases and other pathologies. We also discuss the translational challenges and opportunities of this class of drug-delivery systems and therapeutics.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / drug therapy
Cell Engineering*
Drug Delivery Systems* / methods
Humans
Neoplasms / drug therapy

Abstract

Publication types

MeSH terms

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