Spatial distribution pattern of immune cells is associated with patient prognosis in colorectal cancer

J Transl Med. 2024 Jul 1;22(1):606. doi: 10.1186/s12967-024-05418-x.

Abstract

Background: The spatial context of tumor-infiltrating immune cells (TIICs) is important in predicting colorectal cancer (CRC) patients' clinical outcomes. However, the prognostic value of the TIIC spatial distribution is unknown. Thus, we aimed to investigate the association between TIICs in situ and patient prognosis in a large CRC sample.

Methods: We implemented multiplex immunohistochemistry staining technology in 190 CRC samples to quantify 14 TIIC subgroups in situ. To delineate the spatial relationship of TIICs to tumor cells, tissue slides were segmented into tumor cell and microenvironment compartments based on image recognition technology, and the distance between immune and tumor cells was calculated by implementing the computational pipeline phenoptr.

Results: MPO+ neutrophils and CD68+IDO1+ tumor-associated macrophages (TAMs) were enriched in the epithelial compartment, and myeloid lineage cells were located nearest to tumor cells. Except for CD68+CD163+ TAMs, other cells were all positively associated with favorable prognosis. The prognostic predictive power of TIICs was highly related to their distance to tumor cells. Unsupervised clustering analysis divided colorectal cancer into three subtypes with distinct prognostic outcomes, and correlation analysis revealed the synergy among B cells, CD68+IDO1+TAMs, and T lineage cells in producing an effective immune response.

Conclusions: Our study suggests that the integration of spatial localization with TIIC abundance is important for comprehensive prognostic assessment.

Keywords: Colorectal cancer; Distance to tumor cell; Immune spatial context; Multiplex immunohistochemistry staining; Prognosis.

MeSH terms

  • Aged
  • Cluster Analysis
  • Colorectal Neoplasms* / immunology
  • Colorectal Neoplasms* / pathology
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Macrophages / immunology
  • Macrophages / metabolism
  • Macrophages / pathology
  • Male
  • Middle Aged
  • Prognosis
  • Spatial Analysis
  • Tumor Microenvironment / immunology