Human milk oligosaccharide 2'-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site

J Virol. 2024 Jul 23;98(7):e0086524. doi: 10.1128/jvi.00865-24. Epub 2024 Jul 2.

Authors

Penny A Rudd¹, Gargi Kher², Jeremy R H Tame³, Hiro Irie¹, Thomas Haselhorst^{1

4}, Mark von Itzstein¹, Marie Pancera², Grant S Hansman¹

Affiliations

¹ Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia.
² Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
³ Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama, Japan.
⁴ School of Environment and Science, Griffith University, Gold Coast Campus, Gold Coast, Queensland, Australia.

No abstract available

Keywords: X-ray crystallography; antiviral agents; noroviruses.

Publication types

Letter

MeSH terms

Binding Sites
Blood Group Antigens* / metabolism
Humans
Milk, Human* / chemistry
Norovirus* / drug effects
Norovirus* / metabolism
Oligosaccharides / chemistry
Oligosaccharides / metabolism
Trisaccharides / metabolism

Substances

Blood Group Antigens
2'-fucosyllactose
Oligosaccharides
Trisaccharides