In-vitro studies of the NaV1.5 S805L Brugada mutation: The resting cell voltage is a critical element in determining the pathological or physiological phenotype of the current

Vascul Pharmacol. 2024 Jun:155:107337. doi: 10.1016/j.vph.2024.107337.
No abstract available

MeSH terms

  • Action Potentials
  • Animals
  • Brugada Syndrome* / genetics
  • Brugada Syndrome* / metabolism
  • Brugada Syndrome* / physiopathology
  • Humans
  • Membrane Potentials
  • Mutation*
  • NAV1.5 Voltage-Gated Sodium Channel* / genetics
  • NAV1.5 Voltage-Gated Sodium Channel* / metabolism
  • Phenotype*

Substances

  • NAV1.5 Voltage-Gated Sodium Channel
  • SCN5A protein, human