Chitosan-based crosslinking for controlled topical drug release in rhinosinusitis

Abstract

Chitosan is a promising drug delivery vector for therapeutics owing to its biocompatibility. Once crosslinked with chitosan, prolonged drug release was noted regardless of hydrophilicity. Hydrophilic drugs may require different strategies to obtain a sustained release profile.

Keywords: chitosan; ciprofloxacin; rhinosinusitis; topical drug release; topical steroid.