Iodine-Promoted Sulfoximidation of Cinnamic Acids via Oxidative C═C Bond Cleavage

J Org Chem. 2024 Aug 2;89(15):10472-10484. doi: 10.1021/acs.joc.4c00585. Epub 2024 Jul 15.

Abstract

An iodine-promoted C═C bond cleavage with concomitant decarboxylation and cross-coupling between cinnamic acids and NH-sulfoximines has been developed. This reaction proceeds via selective C═C bond cleavage, followed by decarboxylation and oxidative sulfoximidation. This metal- and base-free protocol involves dioxygen as the source of oxygen, which is facilitated by tert-butyl hydroperoxide (TBHP) as the oxidant affording N-aroylated sulfoximines with good functional group tolerance and good yields.