Advances in Psoriatic Disease Research: Insights From GRAPPA Pilot Research Awardees

Ashley Elliott; Tejpal Gill; Jaehwan Kim; Maria S Shutova; Oliver FitzGerald; Stephen R Pennington; Madeleine Rooney; Atul Deodhar; Siba P Raychaudhuri; Wolf-Henning Boehncke; Kurt de Vlam; Vinod Chandran; Wilson Liao

doi:10.3899/jrheum.2024-0292

Advances in Psoriatic Disease Research: Insights From GRAPPA Pilot Research Awardees

J Rheumatol. 2024 Oct 1;51(Suppl 2):96-100. doi: 10.3899/jrheum.2024-0292.

Authors

Affiliations

¹ A. Elliott, MB Bch BAO, MSc, PhD, M. Rooney, MD, Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
² T. Gill, PhD, A. Deodhar, MD, Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, Oregon, USA.
³ J. Kim, MD, PhD, Department of Dermatology, University of California Davis, Davis, California, and Dermatology Section, Veterans Affairs Northern California Health Care System, Mather, California, and Laboratory for Investigative Dermatology, the Rockefeller University, New York, New York, USA.
⁴ M.S. Shutova, PhD, W.H. Boehncke, MD, University of Geneva, Department of Pathology and Immunology, and University Hospitals of Geneva, Division of Dermatology and Venereology, Geneva, Switzerland.
⁵ O. FitzGerald, MD, S.R. Pennington, PhD, School of Medicine, UCD Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland.
⁶ S.P. Raychaudhuri, MD, Department of Dermatology and Rheumatology, University of California Davis, Davis, and Dermatology and Rheumatology Section, Veterans Affairs Northern California Health Care System, Mather, California, USA.
⁷ K. de Vlam, MD, PhD, Department of Rheumatology, University Hospital, and Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.
⁸ V. Chandran, DM, PhD, Departments of Medicine, Laboratory Medicine and Pathobiology and Institute of Medical Science, University of Toronto, and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
⁹ W. Liao, MD, Department of Dermatology, University of California San Francisco, San Francisco, California, USA. wilson.liao@ucsf.edu.

PMID: 39009398
DOI: 10.3899/jrheum.2024-0292

Abstract

Research progress from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot award program was presented and discussed at the GRAPPA 2023 annual meeting. Topics included identification of protein biomarkers associated with enthesitis in psoriatic arthritis (PsA), the role of HLA-B27 on gut microbial dysbiosis in PsA, single-cell profiling of synovial fluid vs psoriatic skin lesions in PsA, and the role of mechanotransduction in hyperactivation of transforming growth factor-β via αVβ6 integrin in psoriatic epidermis.

Keywords: GRAPPA; biomarker; mechanotransduction; microbiome; psoriasis; psoriatic arthritis.

MeSH terms

Arthritis, Psoriatic*
Awards and Prizes
Biomarkers / metabolism
Biomedical Research / trends
Enthesopathy
HLA-B27 Antigen
Humans
Pilot Projects
Psoriasis*

Substances

Biomarkers
HLA-B27 Antigen