Engineering Native Biological Complexity from the Inside-out and Outside-in

Cole A DeForest; Bruce E Kirkpatrick; Kristi S Anseth

doi:10.1038/s44286-023-00013-1

Engineering Native Biological Complexity from the Inside-out and Outside-in

Nat Chem Eng. 2024 Jan;1(1):2-5. doi: 10.1038/s44286-023-00013-1. Epub 2024 Jan 11.

Authors

Cole A DeForest^{1

2

3

4

5

6}, Bruce E Kirkpatrick^{7

8

9}, Kristi S Anseth^{7

8

10}

Affiliations

¹ Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
² Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
³ Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
⁴ Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
⁵ Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98195, USA.
⁶ Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
⁷ Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80303, USA.
⁸ The BioFrontiers Institute, University of Colorado, Boulder, CO 80303, USA.
⁹ Medical Scientist Training Program, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
¹⁰ Materials Science and Engineering Program, University of Colorado, Boulder, CO 80303, USA.

Abstract

Focusing on engineering control over cell function and fate, this article examines the critical balance of 'outside-in' and 'inside-ouť signaling in tissue development and regeneration. It highlights emerging strategies to manipulate these interactions, including biomaterial design and synthetic biology to influence this delicate equilibrium and fine tune cellular responses.

Abstract

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