Overcoming big bottlenecks in vascular regeneration

Dalia A Fantini; Guang Yang; Astha Khanna; Divya Subramanian; Julie A Phillippi; Ngan F Huang

doi:10.1038/s42003-024-06567-x

Overcoming big bottlenecks in vascular regeneration

Commun Biol. 2024 Jul 18;7(1):876. doi: 10.1038/s42003-024-06567-x.

Authors

Dalia A Fantini¹, Guang Yang^{2

3}, Astha Khanna⁴, Divya Subramanian⁵, Julie A Phillippi^{6

7

8}, Ngan F Huang^{9

10

11

12}

Affiliations

¹ Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
² Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
³ Epicrispr Biotechnologies, Inc, South San Francisco, CA, USA.
⁴ Graver Technologies, Newark, NJ, USA.
⁵ Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
⁶ Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. phillippija@upmc.edu.
⁷ Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. phillippija@upmc.edu.
⁸ McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. phillippija@upmc.edu.
⁹ Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. ngantina@stanford.edu.
¹⁰ Stanford Cardiovascular Institute, Stanford, CA, USA. ngantina@stanford.edu.
¹¹ Department of Chemical Engineering, Stanford University, Stanford, CA, USA. ngantina@stanford.edu.
¹² Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ngantina@stanford.edu.

Abstract

Bioengineering and regenerative medicine strategies are promising for the treatment of vascular diseases. However, current limitations inhibit the ability of these approaches to be translated to clinical practice. Here we summarize some of the big bottlenecks that inhibit vascular regeneration in the disease applications of aortic aneurysms, stroke, and peripheral artery disease. We also describe the bottlenecks preventing three-dimensional bioprinting of vascular networks for tissue engineering applications. Finally, we describe emerging technologies and opportunities to overcome these challenges to advance vascular regeneration.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bioprinting / methods
Blood Vessels / physiology
Humans
Printing, Three-Dimensional
Regeneration*
Regenerative Medicine* / methods
Tissue Engineering* / methods
Vascular Diseases / physiopathology
Vascular Diseases / therapy

Abstract

Publication types

MeSH terms

Grants and funding