Natural products continue to represent a compelling resource for uncovering chemical scaffolds characterised by significant structural variability and diverse biological activities. These compounds possess the potential to be directly utilised or to serve as initial templates for further refinement, ultimately leading to the development of innovative pharmaceutical agents. Among natural products, isoquinoline alkaloids stand out as one of the most extensively researched groups. 1-Oxo-tetrahydroisoquinolinones (1 O-THIQ), isolated from a variety of natural sources, exhibit valuable biological properties. This review investigates the bioactivities of specific 1 O-THIQ alkaloids, which have not been reviewed to the same depth in previous studies.
Keywords: 1-Oxo-tetrahydroisoquinolinones; 1O-thiq; alkaloid; biological activity; natural product.