Chinese expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2022 edition)

Jianchun Duan; Wenfeng Fang; Hairong Xu; Jinliang Wang; Yuan Chen; Yi Ding; Xiaorong Dong; Yun Fan; Beili Gao; Jie Hu; Yan Huang; Cheng Huang; Dingzhi Huang; Wenhua Liang; Lizhu Lin; Hui Liu; Zhiyong Ma; Meiqi Shi; Yong Song; Chuanhao Tang; Jialei Wang; Lifeng Wang; Yongfeng Wang; Zhehai Wang; Nong Yang; Yu Yao; Yan Yu; Qitao Yu; Hongmei Zhang; Jun Zhao; Mingfang Zhao; Zhengfei Zhu; Xiaohui Niu; Li Zhang; Jie Wang

doi:10.1016/j.jncc.2023.08.004

Chinese expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2022 edition)

J Natl Cancer Cent. 2023 Aug 19;3(4):256-265. doi: 10.1016/j.jncc.2023.08.004. eCollection 2023 Dec.

Authors

Jianchun Duan^{1

2}, Wenfeng Fang³, Hairong Xu⁴, Jinliang Wang⁵, Yuan Chen⁶, Yi Ding⁴, Xiaorong Dong⁷, Yun Fan⁸, Beili Gao⁹, Jie Hu¹⁰, Yan Huang³, Cheng Huang¹¹, Dingzhi Huang¹², Wenhua Liang¹³, Lizhu Lin¹⁴, Hui Liu¹⁵, Zhiyong Ma¹⁶, Meiqi Shi¹⁷, Yong Song¹⁸, Chuanhao Tang¹⁹, Jialei Wang²⁰, Lifeng Wang²¹, Yongfeng Wang²², Zhehai Wang²³, Nong Yang²⁴, Yu Yao²⁵, Yan Yu²⁶, Qitao Yu²⁷, Hongmei Zhang²⁸, Jun Zhao²⁹, Mingfang Zhao³⁰, Zhengfei Zhu³¹, Xiaohui Niu⁴, Li Zhang³, Jie Wang¹

Affiliations

¹ CAMS Key Laboratory of Translational Research on Lung Cancer, State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
² Department of Respiratory Medicine, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
³ Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁴ Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
⁵ Department of Oncology and Institute of Translational Medicine, Medical Innovation Research Center and the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
⁶ Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁷ Cancer Center, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁸ Department of Thoracic Medical Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
⁹ Department of Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
¹⁰ Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
¹¹ Department of Medical Oncology, Fujian Cancer Hospital, Fuzhou, China.
¹² Department of Thoracic Medical Oncology, Lung Cancer Diagnosis and Treatment Centre, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Centre for Cancer, Tianjin, China.
¹³ Department of Thoracic Surgery/Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & Health, Guangzhou, China.
¹⁴ Department of Medical Oncology, The First Clinical Medical College, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
¹⁵ Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
¹⁶ Department of Medical Oncology, the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China.
¹⁷ Department of Medical Oncology, Jiangsu Cancer Hospital, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
¹⁸ Department of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
¹⁹ Department of Oncology, Peking University International Hospital, Beijing, China.
²⁰ Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
²¹ Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
²² Department of Respiratory Medicine, Linyi Central Hospital, Linyi, China.
²³ Department of Oncology, Shandong Cancer Hospital, Jinan, China.
²⁴ Department of Medical Oncology, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, China.
²⁵ Department of Oncology Internal Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
²⁶ School of Public Health, Xi'an Jiaotong University, Xi'an, China.
²⁷ Department of Respiratory Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
²⁸ Department of Clinical Oncology, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
²⁹ Department of Thoracic Medical Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
³⁰ Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, China.
³¹ Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Bone is a common metastatic site of lung cancer, about 50% of bone metastatic patients will experience skeletal related events (SREs). SREs not only seriously impact the quality of life of patients, but also shorten their survival time. The treatment of bone metastasis requires multi-disciplinary therapy (MDT) and development of individualized treatment plan. In order to standardize the diagnosis and treatment of bone metastasis in lung cancer, the expert group of the MDT Committee of the Chinese Medical Doctor Association has developed the expert consensus on the diagnosis and treatment of lung cancer bone metastasis.

Keywords: Bone metastasis; Bone-modifying drugs; Lung cancer; Multi-disciplinary therapy.