The nanozymes (NZs) are the artificial catalyst deployed for biosensing with their uniqueness (high robustness, surface tenability, inexpensive, and stability) for obtaining a better response/miniaturization of the varied sensors than their traditional ancestors. Nowadays, nanomaterials with their broadened scale such as metal-organic frameworks (MOFs), and metals/metal oxides are widely engaged in generating NZ-based biosensors (BS). Diverse strategies like fluorescent, colorimetric, surface-enhanced Raman scattering (SERS), and electrochemical sensing principles were implemented for signal transduction of NZs. Despite broad advantages, numerous encounters (like specificity, feasibility, stability, and issues in scale-up) are affecting the potentialities of NZs-based BS, and thus need prior attention for a promising exploration for a revolutionary outcome in advanced theranostics. This review includes different types of NZs, and the progress of numerous NZs tailored bio-sensing techniques in detecting abundant bio analytes for theranostic purposes. Further, the discussion highlighted some recent challenges along with their progressive way of possibly overcoming followed by commercial outbreaks.
Keywords: Biosensors; Catalysis; Metal–organic frameworks; Nanozymes; Theranostic.
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