A tale of two kidneys, and the case for machine perfusion in South Africa

S Afr Med J. 2024 Apr 24;114(3b):e1328. doi: 10.7196/SAMJ.2024.v114i3b.1328.

Abstract

Extended-criteria donors (ECDs) are seen as a means of addressing the shortfall in solid-organ availability for transplant. However, the use of ECD kidneys is associated with a greater risk of primary non-function compared with standard-criteria donor kidneys, and a higher discard rate has been described internationally. There seems to be a lack of consensus in the consideration of ECD kidneys for transplant, with reliance often placed on the subjective assessment of individual clinicians. The following case examines the difference in the institutional decision-making process applied to two kidneys from a single donor, and provides an argument for the use of hypothermic machine perfusion in low- to middle-income countries as an efficacious and objective means of assessing ECD kidney suitability.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Donor Selection / methods
  • Female
  • Humans
  • Kidney / blood supply
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Organ Preservation / methods
  • Perfusion / methods
  • South Africa
  • Tissue Donors
  • Tissue and Organ Procurement / methods