The cyanobacterium Lyngbya majuscula grows in marine and estuarine environments across the world and produces many biologically active compounds. Direct contact with L majuscula and its dermatoxins can cause seaweed dermatitis, which manifests as a papulovesicular eruption. As oceans warm, L majuscula will bloom more frequently; therefore, public awareness of L majuscula and seaweed dermatitis in oceanside communities can help promote precautions that can reduce the risk for exposure. This article describes the irritants that lead to dermatitis, clinical presentation, and prevention and management of seaweed dermatitis.