Congenital Syphilis-Comprehensive Narrative Review of Alternative Antibiotic Treatment for Use in Neonates

Sex Transm Dis. 2024 Dec 1;51(12):775-779. doi: 10.1097/OLQ.0000000000002057. Epub 2024 Jul 24.

Abstract

Congenital syphilis rates increased 10-fold from 2012 to 2022 in the United States. Currently, the therapeutic standard of care is 10 days of intravenous aqueous crystalline penicillin G, with very limited evidence for alternatives. A long course of intravenous antibiotic requires hospitalization that is both costly and burdensome for the child and the family. Fortunately, Treponema pallidum retains susceptibility to other antibiotics based on minimum inhibitory concentrations. Based on the evidence of safety and efficacy of different antibiotics for use in neonates, ceftriaxone emerges as a potential parenteral candidate, and amoxicillin emerges as a potential oral candidate for the treatment of congenital syphilis. Other therapeutic alternatives include cefotaxime (where available), ampicillin, doxycycline, cefixime, and linezolid.

Publication types

  • Review

MeSH terms

  • Amoxicillin / administration & dosage
  • Ampicillin / administration & dosage
  • Anti-Bacterial Agents* / administration & dosage
  • Anti-Bacterial Agents* / therapeutic use
  • Cefotaxime / administration & dosage
  • Cefotaxime / therapeutic use
  • Ceftriaxone / administration & dosage
  • Doxycycline / administration & dosage
  • Doxycycline / therapeutic use
  • Female
  • Humans
  • Infant, Newborn
  • Linezolid / administration & dosage
  • Linezolid / therapeutic use
  • Microbial Sensitivity Tests
  • Penicillin G / administration & dosage
  • Penicillin G / therapeutic use
  • Syphilis, Congenital* / drug therapy
  • Treponema pallidum* / drug effects

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone
  • Amoxicillin
  • Linezolid
  • Cefotaxime
  • Doxycycline
  • Ampicillin
  • Penicillin G