Diaphragmatic palsy following lung transplantation

Eur Respir Rev. 2024 Jul 24;33(173):230270. doi: 10.1183/16000617.0270-2023. Print 2024 Jul.

Abstract

Diaphragmatic palsy after lung transplantation has been reported infrequently. Given the role of the diaphragm in respiration, the palsy may play a significant role in the post-surgical recovery as well as morbidity and mortality. This review summarises the current literature to better understand diaphragmatic palsy in the post lung-transplant setting among adults. A thorough literature search was conducted through multiple databases and 91 publications were identified that fit the research question. The review aimed to report the burden of this problem, explore different modalities of diagnosis reported, the effect of various clinical factors and treatment modalities, as well as their effects on outcomes. Additionally, it aimed to highlight the variability, limitations of reported data, and the absence of a standardised approach. This review emphasises the crucial need for more dedicated research to better address this clinical challenge.

Publication types

  • Review

MeSH terms

  • Adult
  • Diaphragm / physiopathology
  • Female
  • Humans
  • Lung Transplantation* / adverse effects
  • Male
  • Recovery of Function
  • Respiratory Paralysis* / etiology
  • Respiratory Paralysis* / physiopathology
  • Respiratory Paralysis* / therapy
  • Risk Factors
  • Treatment Outcome