Low skin temperatures produced by new skin refrigerants

J Dermatol Surg Oncol. 1985 Dec;11(12):1196-8. doi: 10.1111/j.1524-4725.1985.tb03095.x.

Abstract

Temperatures produced by Cryosthesia -30 degrees C, Cryosthesia -60 degrees C, and Frigiderm were measured in minipigs. Cryosthesia -60 degrees C and Cryosthesia -30 degrees C were both found to rapidly lower skin temperatures to levels that have been shown to cause cell injury, necrosis, and loss of melanocytes. Use of these agents requires extreme caution in dermabrasion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chlorofluorocarbons, Ethane
  • Chlorofluorocarbons, Methane / pharmacology*
  • Cryosurgery / methods
  • Dermabrasion / methods
  • Drug Evaluation, Preclinical
  • Skin Temperature / drug effects*
  • Swine
  • Swine, Miniature
  • Time Factors

Substances

  • Chlorofluorocarbons, Ethane
  • Chlorofluorocarbons, Methane
  • Cryosthesia -30 C
  • Freon 114
  • dichlorodifluoromethane