Doxycycline, a role in the treatment of onchocerciasis-associated epilepsy?

Trends Parasitol. 2024 Aug;40(8):667-669. doi: 10.1016/j.pt.2024.06.005. Epub 2024 Jul 25.

Abstract

Can the antibiotic doxycycline unlock new possibilities in the fight against onchocerciasis-associated epilepsy (OAE)? Idro et al. explored this question by investigating for the first time doxycycline's impact on nodding syndrome (NS), a severe manifestation of OAE. Results reveal significant findings that may shape future treatment strategies.

Keywords: clinical trial; doxycycline; epilepsy; nodding syndrome; onchocerciasis; pathogenesis.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Doxycycline* / therapeutic use
  • Epilepsy* / drug therapy
  • Humans
  • Nodding Syndrome / complications
  • Nodding Syndrome / drug therapy
  • Onchocerciasis* / complications
  • Onchocerciasis* / drug therapy

Substances

  • Doxycycline
  • Anti-Bacterial Agents