Autoimmune 'secondary synaptopathies': do NMDAR antibodies cause a primary extra-synaptopathy?

Meng Zhao; David R Lynch; Sarosh R Irani

doi:10.1093/brain/awae236

Autoimmune 'secondary synaptopathies': do NMDAR antibodies cause a primary extra-synaptopathy?

Brain. 2024 Aug 1;147(8):2601-2603. doi: 10.1093/brain/awae236.

Authors

Meng Zhao^{1

2}, David R Lynch³, Sarosh R Irani^{1

2

4

5}

Affiliations

¹ Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
² Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
³ Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
⁴ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
⁵ Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals, Oxford OX3 9DU, UK.

Abstract

This scientific commentary refers to ‘NMDA receptor autoantibodies primarily impair the extrasynaptic compartment’ by Jamet et al. (https://doi.org/10.1093/brain/awae163).

Publication types

Editorial
Comment

MeSH terms

Animals
Autoantibodies* / immunology
Autoimmune Diseases / immunology
Humans
Receptors, N-Methyl-D-Aspartate* / immunology
Synapses / pathology

Substances

Receptors, N-Methyl-D-Aspartate
Autoantibodies

Abstract

Publication types

MeSH terms

Substances

Grants and funding