Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases

Juan Gao; Jiaxin Song; Yuwei Yan; Priyanka Gokulnath; Gururaja Vulugundam; Guoping Li; Qingyi Zhan; Fei Jiang; Yanjuan Lin; Junjie Xiao

doi:10.31083/j.rcm2409251

Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases

Rev Cardiovasc Med. 2023 Sep 6;24(9):251. doi: 10.31083/j.rcm2409251. eCollection 2023 Sep.

Authors

Juan Gao^{1

2}, Jiaxin Song^{1

2}, Yuwei Yan^{1

2}, Priyanka Gokulnath³, Gururaja Vulugundam⁴, Guoping Li³, Qingyi Zhan^{1

2}, Fei Jiang^{5

6}, Yanjuan Lin^{5

6}, Junjie Xiao^{1

2}

Affiliations

¹ Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, 226011 Nantong, Jiangsu, China.
² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 200444 Shanghai, China.
³ Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁴ Biologics Development, Sanofi, Framingham, MA 01701, USA.
⁵ Department of Nursing, Union Hospital, Fujian Medical University Union Hospital, 350001 Fuzhou, Fujian, China.
⁶ Fujian Provincial Special Reserve Talents Laboratory, Fujian Medical University Union Hospital, 350001 Fuzhou, Fujian, China.

Abstract

Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood. However, mounting evidence suggest that microRNAs (miRNAs) play crucial role in this process and are essential in responding to exercise-stress and mediating exercise-protective effects. Thus, this review summarizes the biogenesis of miRNAs, the mechanism of miRNA action, and specifically the miRNAs involved in exercise-induced cardio-protection used as therapeutic targets for treating cardiovascular diseases.

Keywords: beneficial adaption; cardiovascular diseases; exercise training; microRNA; therapeutic targets.

Publication types

Review

Grants and funding

This work was supported by the grants from National Natural Science Foundation of China (82020108002 and 82225005 to JJ Xiao, 82170390 to J GAO), the grant from Science and Technology Commission of Shanghai Municipality (21XD1421300 and 20DZ2255400 to JJ Xiao, 21ZR1422700 to J Gao), and the “Dawn” Program of Shanghai Education Commission (19SG34 to JJ Xiao).